Sant'Andrea in Via Flaminia, also called Sant'Andrea del Vignola, stands on Via Flaminia in Rome, near the Villa Giulia. Pope Julius III commissioned it to fulfill a vow related to his escape during the Sack of Rome in 1527. Giacomo Barozzi da Vignola designed it in 1552, after groundbreaking in 1550, and it was completed in 1554. It is dedicated to St. Andrew the Apostle.
The exterior is an unadorned cube of gray pietra serena stone. A low elliptical dome sits behind a high, plain drum, and the church is described as the first with an elliptical dome. The street front is a flat temple facade with Corinthian pilasters and shell-headed niches beside the door.
Girolamo Siciolante da Sermoneta and Pellegrino Tibaldi painted frescoes inside. The church was long neglected. Giuseppe Valadier refurbished it in 1805.
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